Oral Hyaluronic Acid (HA) Supplementation in liquid form

    HA supplements in tablet or capsule form have been available for sometime but the quality of HA varies enormously. Some tablets have low grade HA and poor absorbtion in the gut and most gelatine capsules have gelatine of animal origin which, since CJD, consumers want to avoid.

    A major breakthrough has been the development of a liquid formulation of HA which is rapidly absorbed in the gut and appears in the joints in less than 60 minutes and it remains in the joints for at least five hours reducing pain and improving joint lubrication and mobility. (J. Agric. Food Chem.2008, 56, 10582-10593). This proven, effective, oral, liquid version of HA is known as Novisyn.

    Oral HA Supplementation - benefits usually noticed around 7 days

    • Improves pain and stiffness

    • It is anti-inflammatory

    • Has lubricating effects

    • Increases the concentration of HA in the cells of the joint lining

    Absobtion of Oral Hyaluronic Acid

    • After ONE oral administration HA is absorbed and distributed to the organs and joints

    • Within 30 MINUTES HA can be detected in blood mucas, salicva, glands and bone and peaked at around 6 hours.

    • Less than 5% appeared in faeces after 72 hours.

    Why size is important

    HA is described as being low, medium and high in molecular weight (MW)

    LOW MW HA - 5,000 - 500,000 DA

    1. Once in the stomach it is degraded by the stomach acids and therefore not available to the joints

    MEDIUM MW HA - 600,000 DA to 2M DA

    1. Sufficiently robust to pass through the stomach and is absorbed in the intestine and made available to the joints

    HIGH MW HA - 2M DA+

    1. Can not be made available to the joints because the molecular weight is too high to be absorbed in the intestine.

    Novisyn Oral Hyaluronan

    • Mid moecular weight Hyaluronan 1.2 to 1.5m DA (17mg)

    • Not degraded in the stomach but absorbed by the intestine

    • Produced by a natural fermentation process

    • Suitable for vegetarians and vegans

    • Safe with no known side effects

    • Easy to take liquid formula



    References:

    American Institute for Biosocial and Medical Research

    National Institute of Health - Hungary